Article

Traumatic Brain Injury Exacerbates Alzheimer’s Disease Pathology in the Retinas of TgF344-AD Rats

2021-09-24

Abstract excerpt

Alzheimer’s disease (AD) is a neurodegenerative condition that affects 6.2 million people age 65 and older in the U.S. alone, and is the leading cause of dementia. Moreover, AD can lead to visual impairment, and AD histopathology also manifests in the retina. However, the factors that modulate AD pathophysiology and lead to varied susceptibility and presentation in the population are not well understood. In this c...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 266c4ee5-bcc1-596b-be0b-8decd975d2be
DOI: 10.1101/2021.09.23.461334

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

Traumatic Brain Injury Exacerbates Alzheimer’s Disease Pathology in the Retinas of TgF344-AD RatsDOI 10.1101/2021.09.23.461334Read

Traumatic brain injury in mice generates early-stage Alzheimer’s disease related protein pathology that correlates with neurobehavioral deficitsSemantic proximity Read

Traumatic Brain Injury Induces Tau Aggregation and SpreadingSemantic proximity Read

Evidence for accelerated tauopathy in the retina of transgenic P301S tau mice exposed to repetitive mild traumatic brain injury.Semantic proximity Read

Mammalian Models in Alzheimer's Research: An updateSemantic proximity Read

Thy1-ApoE4/C/EBPβ double transgenic mice act as a sporadic model with Alzheimer's disease.Semantic proximity Read

Traumatic Brain Injury Accelerates the Onset of Cognitive Dysfunction and Aggravates Alzheimer’s-like Pathology in the Hippocampus by Altering the Phenotype of Microglia in APP/PS1 Mouse ModelSemantic proximity Read

Brain trauma in aged transgenic mice induces regression of established abeta deposits.Semantic proximity Read

Traumatic brain injury: cause or risk of Alzheimer's disease? A review of experimental studies.Semantic proximity Read

Animal models of Alzheimer's disease: Applications, evaluation, and perspectives.Semantic proximity Read

Insights From TgF344-AD, a Double Transgenic Rat Model in Alzheimer’s Disease ResearchSemantic proximity Read

Rodent models for Alzheimer’s disease drug discoverySemantic proximity Read

Alzheimer’s Disease Risk Factors: APOE ε4 Allele and Traumatic Brain InjuriesSemantic proximity Read