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Article

Distinct temporal and anatomical distributions of amyloid-β and tau abnormalities following controlled cortical impact in transgenic mice.

PloS one - 1 Jan 2011

Tran Hien T, Sanchez Laura, Esparza Thomas J, Brody David L

Abstract excerpt

Traumatic brain injury (TBI) is a major environmental risk factor for Alzheimer's disease. Intracellular accumulations of amyloid-β and tau proteins have been observed within hours following severe TBI in humans. Similar abnormalities have been recapitulated in young 3xTg-AD mice subjected to the controlled cortical impact model (CCI) of TBI and sacrificed at 24 h and 7 days post injury. This study investigated...

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Source

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Identifiers

PMID: 21980472
DOI: 10.1371/journal.pone.0025475
PMCID: PMC3183029

Genes

APP

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