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Article

Age at injury and genotype modify acute inflammatory and neurofilament-light responses to mild CHIMERA traumatic brain injury in wild-type and APP/PS1 mice.

Experimental neurology - 1 Mar 2018

Cheng Wai Hang, Stukas Sophie, Martens Kris M, Namjoshi Dhananjay R, Button Emily B, Wilkinson Anna, Bashir Asma, Robert Jerome, Cripton Peter A, Wellington Cheryl L

Abstract excerpt

Peak incidence of traumatic brain injury (TBI) occurs in both young and old individuals, and older age at injury is associated with worse outcome and poorer recovery. Moderate-severe TBI is a reported risk factor for dementia, including Alzheimer's disease (AD), but whether mild TBI (mTBI) alters AD pathogenesis is not clear. To delineate how age at injury and predisposition to amyloid formation affect the acute...

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Source

Identifiers

PMID: 29269117
DOI: 10.1016/j.expneurol.2017.12.007

Genes

APP

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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