Article
Brain trauma in aged transgenic mice induces regression of established abeta deposits.
Experimental neurology - 1 May 2000
Nakagawa Y, Reed L, Nakamura M, McIntosh T K, Smith D H, Saatman K E, Raghupathi R, Clemens J, Saido T C, Lee V M, Trojanowski J Q
Abstract excerpt
Traumatic brain injury (TBI) increases susceptibility to Alzheimer's disease (AD), but it is not known if TBI affects the progression of AD. To address this question, we studied the neuropathological consequences of TBI in transgenic (TG) mice with a mutant human Abeta precursor protein (APP) min...
Topics
- Aging
- Alzheimer Disease
- Amyloid beta-Peptides
- Animals
- Brain Injuries
- Cell Death
- Disease Progression
- Female
- Gliosis
- Head Injuries, Closed
- Hippocampus
- Humans
- Immunohistochemistry
- In Situ Nick-End Labeling
- Mice