Article
Brain trauma in aged transgenic mice induces regression of established abeta deposits.
Experimental neurology - 1 May 2000
Nakagawa Y, Reed L, Nakamura M, McIntosh T K, Smith D H, Saatman K E, Raghupathi R, Clemens J, Saido T C, Lee V M, Trojanowski J Q
Abstract excerpt
Traumatic brain injury (TBI) increases susceptibility to Alzheimer's disease (AD), but it is not known if TBI affects the progression of AD. To address this question, we studied the neuropathological consequences of TBI in transgenic (TG) mice with a mutant human Abeta precursor protein (APP) mini-gene driven by a platelet-derived (PD) growth factor promoter resulting in overexpression of mutant APP (V717F),...
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