Article

Development of a targeted next-generation sequencing gene panel to investigate recurrent mutations in chronic lymphocytic leukaemia

2016-01-01

Abstract excerpt

Chronic lymphocytic leukaemia (CLL) is a mono-clonal B-cell malignancy characterised by heterogeneous clinical course and response to treatment. Recent studies with whole genome or whole exome sequencing have identified novel recurrent genomic lesions, and associated them with adverse clinical outcome of this disease. Owing to their limited sensitivity, the true incidence of these mutations, subclonal complexity a...

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Literature Corpus work: 70cfd887-9480-56fc-8566-488108b5572f
DOI: 10.17638/03004906

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