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Article

Recurrent gene mutations in CLL.

Advances in experimental medicine and biology - 1 Jan 2013

Martínez-Trillos Alejandra, Quesada Víctor, Villamor Neus, Puente Xose S, López-Otín Carlos, Campo Elías

Abstract excerpt

Next-generation sequencing of whole genomes and exomes in chronic lymphocytic leukemia (CLL) has provided the first comprehensive view of somatic mutations in this disease. Subsequent studies have characterized the oncogenic pathways and clinical implications of a number of these mutations. The global number of somatic mutations per case is lower than those described in solid tumors but is in agreement with...

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Share to NOTCH1 gene
Share to Leukemia, Lymphocytic, Chronic, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Myeloid Differentiation Factor 88

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Share to Receptor, Notch1

Share to Ribonucleoprotein, U2 Small Nuclear

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Source

Identifiers

PMID: 24014293
DOI: 10.1007/978-1-4614-8051-8_4

Genes

NOTCH1

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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