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Article

Comprehensive Analysis of Disease-Related Genes in Chronic Lymphocytic Leukemia by Multiplex PCR-Based Next Generation Sequencing.

PloS one - 1 Jan 2015

Vollbrecht Claudia, Mairinger Fabian Dominik, Koitzsch Ulrike, Peifer Martin, Koenig Katharina, Heukamp Lukas Carl, Crispatzu Giuliano, Wilden Laura, Kreuzer Karl-Anton, Hallek Michael, Odenthal Margarete, Herling Carmen Diana, Buettner Reinhard

Abstract excerpt

BACKGROUND: High resolution molecular studies have demonstrated that the clonal acquisition of gene mutations is an important mechanism that may promote rapid disease progression and drug resistance in chronic lymphocytic leukemia (CLL). Therefore, the early and sensitive detection of such mutations is an important prerequisite for future predictive CLL diagnostics in the clinical setting. MATERIAL & METHODS:...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

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Identifiers

PMID: 26053404
DOI: 10.1371/journal.pone.0129544
PMCID: PMC4459702

Genes

ATM
MYD88
NOTCH1
PTPN6
XPO1
ZAP70

Provenance

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