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Article

A Quantitative Analysis of Subclonal and Clonal Gene Mutations before and after Therapy in Chronic Lymphocytic Leukemia.

Clinical cancer research : an official journal of the American Association for Cancer Research - 1 Sept 2016

Amin Nisar A, Seymour Erlene, Saiya-Cork Kamlai, Parkin Brian, Shedden Kerby, Malek Sami N

Abstract excerpt

PURPOSE: Chronic lymphocytic leukemia (CLL)-associated gene mutations that influence CLL cell fitness and chemotherapy resistance should increase in clonal representation when measured before therapy and at relapse. EXPERIMENTAL DESIGN: To uncover mutations associated with CLL relapse, we have performed whole-exome sequencing in a discovery cohort of 61 relapsed CLL patients identifying 86 recurrently mutated...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Clonal Evolution

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Share to Leukemia, Lymphocytic, Chronic, B-Cell

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Source

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Identifiers

PMID: 27060156
DOI: 10.1158/1078-0432.CCR-15-3103
PMCID: PMC5010528

Genes

SAMHD1
CHD2
FAT3
MGA
MYD88
NOTCH1
NXF1
POT1
XPO1
ZMYM3

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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