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Design and MinION testing of a nanopore targeted gene sequencing panel for chronic lymphocytic leukemia

1 Aug 2018

Abstract excerpt

We report a customized gene panel assay based on multiplex long-PCR followed by third generation sequencing on nanopore technology (MinION), designed to analyze five frequently mutated genes in chronic lymphocytic leukemia (CLL): TP53, NOTCH1, BIRC3, SF3B1 and MYD88. For this purpose, 12 patients were selected according to specific cytogenetic and molecular features significantly associated with their mutational...

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PMID: 30087429
DOI: 10.1038/s41598-018-30330-y

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