Article
Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting.
Haematologica - 1 Mar 2015
Sutton Lesley-Ann, Ljungström Viktor, Mansouri Larry, Young Emma, Cortese Diego, Navrkalova Veronika, Malcikova Jitka, Muggen Alice F, Trbusek Martin, Panagiotidis Panagiotis, Davi Frederic, Belessi Chrysoula, Langerak Anton W, Ghia Paolo, Pospisilova Sarka, Stamatopoulos Kostas, Rosenquist Richard
Abstract excerpt
Next-generation sequencing has revealed novel recurrent mutations in chronic lymphocytic leukemia, particularly in patients with aggressive disease. Here, we explored targeted re-sequencing as a novel strategy to assess the mutation status of genes with prognostic potential. To this end, we utilized HaloPlex targeted enrichment technology and designed a panel including nine genes: ATM, BIRC3, MYD88, NOTCH1, SF3B1...
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