Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1.

Haematologica - 1 Oct 2020

Tausch Eugen, Beck Philipp, Schlenk Richard F, Jebaraj Billy J, Dolnik Anna, Yosifov Deyan Y, Hillmen Peter, Offner Fritz, Janssens Ann, Babu Govind K, Grosicki Sebastian, Mayer Jiri, Panagiotidis Panagiotis, McKeown Astrid, Gupta Ira V, Skorupa Alexandra, Pallaud Celine, Bullinger Lars, Mertens Daniel, Döhner Hartmut, Stilgenbauer Stephan

Abstract excerpt

Next generation sequencing studies in Chronic lymphocytic leukemia (CLL) have revealed novel genetic variants that have been associated with disease characteristics and outcome. The aim of this study was to evaluate the prognostic value of recurrent molecular abnormalities in patients with CLL. Therefore, we assessed their incidences and associations with other clinical and genetic markers in the prospective...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Leukemia, Lymphocytic, Chronic, B-Cell

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Mutation

Share to Phosphoproteins

Share to Prognosis

Share to Receptor, Notch1

Share to RNA Splicing Factors

Source

Open in PubMed Open full text

Identifiers

PMID: 33054084
DOI: 10.3324/haematol.2019.229161
PMCID: PMC7556677

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Prognostic and predictive role of gene mutations in chronic lymphocytic leukemia: results from the pivotal phase III study COMPLEMENT1.PMID 33054084Read ↗

Gene Mutations and Treatment Outcome in Chronic Lymphocytic Leukemia: Results From the CLL8 TrialSemantic proximity Read ↗

Gene mutations and treatment outcome in chronic lymphocytic leukemia: results from the CLL8 trial.Semantic proximity Read ↗

Molecular genetics of high-risk chronic lymphocytic leukemia.Semantic proximity Read ↗

Recurrent mutations refine prognosis in chronic lymphocytic leukemia.Semantic proximity Read ↗

The mutational landscape of chronic lymphocytic leukemia and its impact on prognosis and treatmentSemantic proximity Read ↗

Clinical significance of TP53, BIRC3, ATM and MAPK-ERK genes in chronic lymphocytic leukaemia: data from the randomised UK LRF CLL4 trial.Semantic proximity Read ↗

Extensive next-generation sequencing analysis in chronic lymphocytic leukemia at diagnosis: clinical and biological correlationsSemantic proximity Read ↗

Targeted next-generation sequencing in chronic lymphocytic leukemia: a high-throughput yet tailored approach will facilitate implementation in a clinical setting.Semantic proximity Read ↗

Genomic Features: Impact on Pathogenesis and Treatment of Chronic Lymphocytic Leukemia.Semantic proximity Read ↗

Predicting Prognosis in Chronic Lymphocytic Leukemia in the Contemporary Era.Semantic proximity Read ↗

Different prognostic impact of recurrent gene mutations in chronic lymphocytic leukemia depending on IGHV gene somatic hypermutation status: a study by ERIC in HARMONY.Semantic proximity Read ↗

Prognostic impact of genetic abnormalities in 536 first-line chronic lymphocytic leukaemia patients without 17p deletion treated with chemoimmunotherapy in two prospective trials: Focus on IGHV-mutated subgroups (a FILO study).Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.