Article
Chronic Lymphocytic Leukemia IGHV Somatic Hypermutation Detection by Targeted Capture Next-Generation Sequencing.
Clinical chemistry - 4 Jan 2024
Grants Jennifer M, May Christina, Bridgers Josh, Huang Shujun, Gillis Sierra, Meissner Barbara, Boyle Merrill, Ben-Neriah Susana, Hung Stacy, Duns Gerben, Hilton Laura, Gerrie Alina S, Marra Marco, Kridel Robert, Sabatini Peter J B, Steidl Christian, Scott David W, Karsan Aly
Abstract excerpt
BACKGROUND: Somatic hypermutation (SHM) status of the immunoglobulin heavy variable (IGHV) gene plays a crucial role in determining the prognosis and treatment of patients with chronic lymphocytic leukemia (CLL). A common approach for determining SHM status is multiplex polymerase chain reaction and Sanger sequencing of the immunoglobin heavy locus; however, this technique is low throughput, is vulnerable to...
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