Article

Peripheral metabolic dysfunction drives sleep disruption in TDP-43 proteinopathy

2026-02-24

Abstract excerpt

Sleep disruption is an early and prevalent feature of neurodegenerative disease, commonly attributed to neuronal circuit dysfunction or cell loss. However, sleep is tightly coupled to metabolic state, raising the possibility that systemic metabolic abnormalities contribute to disease-associated sleep phenotypes. Using Drosophila models of TDP-43 proteinopathy, we investigated whether peripheral metabolic dysfunct...

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Literature Corpus work: 70ca6e43-ea42-508b-9f27-2cadd7d07ca4
DOI: 10.64898/2026.02.23.707321

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