Article

A salt-induced kinase (SIK) is required for the metabolic regulation of sleep

2019-03-22

Abstract excerpt

<h4>ABSTRACT</h4> Many lines of evidence point to links between sleep regulation and energy homeostasis, but mechanisms underlying these connections are unknown. During C. elegans sleep, energetic stores are allocated to non-neural tasks with a resultant drop in the overall fat stores and energy charge. Mutants lacking KIN-29, the C. elegans homolog of a mammalian Salt-Inducible Kinase (SIK) that signals sleep...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 10c98794-c06d-56fa-aced-a506718791a8
DOI: 10.1101/586701

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

A salt-induced kinase (SIK) is required for the metabolic regulation of sleepDOI 10.1101/586701Read

A salt-induced kinase is required for the metabolic regulation of sleep.Semantic proximity Read

Regulation of chemosensory receptor expression and sensory signaling by the KIN-29 Ser/Thr kinase.Semantic proximity Read

Peripheral metabolic dysfunction drives sleep disruption in TDP-43 proteinopathySemantic proximity Read

The NALCN channel complex is necessary for stabilizing sleep in Caenorhabditis elegans.Semantic proximity Read

Sleep Counteracts Aging Phenotypes to Survive Starvation-Induced Developmental Arrest in C. elegansSemantic proximity Read

A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79Semantic proximity Read

Obesity and the regulation of fat metabolismSemantic proximity Read

Polygenic control of Caenorhabditis elegans fat storage.Semantic proximity Read

The nuclear pore complex connects energy sensing to transcriptional plasticity in longevitySemantic proximity Read

skn-1 is required for interneuron sensory integration and foraging behavior in Caenorhabditis elegans.Semantic proximity Read

KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC.Semantic proximity Read

Intracellular sodium sensing: SIK1 network, hormone action and high blood pressure.Semantic proximity Read