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Interaction of <i>G2019S LRRK2</i> and metabolic syndrome in a two-hit mouse model of Parkinson’s disease: LRRK2-driven systemic depletion of pyrimidine nucleosides

2026-01-02

Abstract excerpt

G2019S LRRK2 is the most common cause of familial Parkinson’s disease (PD) and is associated with sporadic PD, arising from the interplay of genetic predisposition, environmental exposure and aging. Metabolic syndrome is implicated as a risk factor for PD, but the interaction between G2019S LRRK2 and metabolic stress in disease pathogenesis remains unclear. We employed high-fat diet (HFD) feeding to induce metabo...

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Literature Corpus work
8f03731f-2a6b-54d7-9377-490a003b9223
DOI
10.64898/2025.12.31.697225
Open publication

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Interaction of <i>G2019S LRRK2</i> and metabolic syndrome in a two-hit mouse model of Parkinson’s disease: LRRK2-driven systemic depletion of pyrimidine nucleosidesDOI 10.64898/2025.12.31.697225
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