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Article

TDP-43 impairs sleep in Drosophila through Ataxin-2 –dependent metabolic disturbance

10 Jan 2024

Abstract excerpt

Neurodegenerative diseases such as amyotrophic lateral sclerosis and frontotemporal dementia are associated with substantial sleep disruption, which may accelerate cognitive decline and brain degeneration. Here, we define a role for trans-activation response element (TAR) DNA binding protein 43 (TDP-43), a protein associated with human neurodegenerative disease, in regulating sleep using Drosophila . Expression...

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PMID: 38198547
DOI: 10.1126/sciadv.adj4457

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