Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

A salt-induced kinase is required for the metabolic regulation of sleep.

PLoS biology - 1 Apr 2020

Grubbs Jeremy J, Lopes Lindsey E, van der Linden Alexander M, Raizen David M

Abstract excerpt

Many lines of evidence point to links between sleep regulation and energy homeostasis, but mechanisms underlying these connections are unknown. During Caenorhabditis elegans sleep, energetic stores are allocated to nonneural tasks with a resultant drop in the overall fat stores and energy charge. Mutants lacking KIN-29, the C. elegans homolog of a mammalian Salt-Inducible Kinase (SIK) that signals sleep pressure,...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Adenosine Triphosphate
Share to Animals, Genetically Modified
Share to Caenorhabditis elegans

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Caenorhabditis elegans Proteins

Share to Energy Metabolism

Share to Histone Deacetylases

Share to Sensory Receptor Cells

Source

Open in PubMed Open full text

Identifiers

PMID: 32315298
DOI: 10.1371/journal.pbio.3000220
PMCID: PMC7173979

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

A salt-induced kinase is required for the metabolic regulation of sleep.PMID 32315298Read ↗

A salt-induced kinase (SIK) is required for the metabolic regulation of sleepSemantic proximity Read ↗

Regulation of chemosensory receptor expression and sensory signaling by the KIN-29 Ser/Thr kinase.Semantic proximity Read ↗

Peripheral metabolic dysfunction drives sleep disruption in TDP-43 proteinopathySemantic proximity Read ↗

The NALCN channel complex is necessary for stabilizing sleep in Caenorhabditis elegans.Semantic proximity Read ↗

A screen for sleep and starvation resistance identifies a wake-promoting role for the auxiliary channel unc79Semantic proximity Read ↗

Sleep Counteracts Aging Phenotypes to Survive Starvation-Induced Developmental Arrest in C. elegansSemantic proximity Read ↗

Obesity and the regulation of fat metabolismSemantic proximity Read ↗

KIN-29 SIK regulates chemoreceptor gene expression via an MEF2 transcription factor and a class II HDAC.Semantic proximity Read ↗

The nuclear pore complex connects energy sensing to transcriptional plasticity in longevitySemantic proximity Read ↗

Polygenic control of Caenorhabditis elegans fat storage.Semantic proximity Read ↗

Neuronal HSF-1 coordinates the propagation of fat desaturation across tissues to enable adaptation to high temperatures in C. elegans.Semantic proximity Read ↗

Neural and molecular dissection of a C. elegans sensory circuit that regulates fat and feeding.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.