Article

POLD replicates both strands of small kilobase-long replication bubbles initiated at a majority of human replication origins

2017-08-10

Abstract excerpt

Error-prone mutants of polymerase epsilon (POLE*) or polymerase delta (POLD1*) induce a mutator phenotype in human cancers. Here we show that the rate of mutations introduced by POLD1* is elevated by 50%, while the rate of POLE*-induced mutations is decreased twofold, within one kilobase from replication origins. These results support a model in which POLD1 replicates both the leading and the lagging strands withi...

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Identifiers and source

Literature Corpus work: ade15f89-2728-5a76-b3ab-421fc1867ac5
DOI: 10.1101/174730

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