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Article

The evolving tale of Pol2 function.

Genes & development - 1 Feb 2023

Gallitto Matthew, Zhang Zhiguo

Abstract excerpt

DNA replication is complex and highly regulated, and DNA replication errors can lead to human diseases such as cancer. DNA polymerase ε (polε) is a key player in DNA replication and contains a large subunit called POLE, which possesses both a DNA polymerase domain and a 3'-5' exonuclease domain (EXO). Mutations at the EXO domain and other missense mutations on POLE with unknown significance have been detected in...

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Identifiers

PMID: 36813532
DOI: 10.1101/gad.350527.123
PMCID: PMC10069447

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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