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Pilot study demonstrating changes in DNA hydroxymethylation enable detection of multiple cancers in plasma cell-free DNA

2020-01-27

Abstract excerpt

<h4>ABSTRACT</h4> Our study employed the detection of 5-hydroxymethyl cytosine (5hmC) profiles on cell free DNA (cfDNA) from the plasma of cancer patients using a novel enrichment technology coupled with sequencing and machine learning based classification method. These classification methods were develo i ped to detect the presence of disease in the plasma of cancer and control subjects. Cancer and control patien...

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Literature Corpus work: 70c5d91e-1838-53ab-94c9-6743e541405c
DOI: 10.1101/2020.01.22.20018382

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