Article

Machine Learning–Based Classification of Cancer Using Promoter-Associated 5-Hydroxymethylcytosine Signatures in Cell-Free DNA

2026-09-01

Abstract excerpt

<title>Abstract</title> <p>Cancer is a leading cause of global mortality, with its biological complexity and molecular heterogeneity posing significant challenges to early diagnosis and clinical management. Among emerging epigenetic biomarkers, 5hydroxymethylcytosine (5hmC), an oxidative derivative of 5-methylcytosine generated by ten-eleven translocation (TET) enzymes, has demonstrated strong potential for non-i...

Identifiers and source

Literature Corpus work: d4494ad2-62de-52da-9169-bbf000c6c365
DOI: 10.21203/rs.3.rs-10868632/v1

Open publication

Related research

Semantic proximity does not establish scientific evidence. Graph snapshot: 2026-09-29.

Click a neighbor to travelStep 1 · 12 closest

Machine Learning–Based Classification of Cancer Using Promoter-Associated 5-Hydroxymethylcytosine Signatures in Cell-Free DNADOI 10.21203/rs.3.rs-10868632/v1Read

Machine learning identifies cell-free DNA 5-hydroxymethylation biomarkers that detect occult colorectal cancer in PLCO Screening Trial subjectsSemantic proximity Read

DNA 5-Hydroxymethylcytosines from Cell-free Circulating DNA as Diagnostic Biomarkers for Human CancersSemantic proximity Read

5-Hydroxymethylcytosine signatures in cell-free DNA provide information about tumor types and stagesSemantic proximity Read

ATAC-seq Guided Interpretable Machine Learning Reveals Cancer-Specific Chromatin Features in Cell-free DNASemantic proximity Read

Sensitive and specific multi-cancer detection and localization using methylation signatures in cell-free DNASemantic proximity Read

Plasma cell-free DNA as a sensitive biomarker for multi-cancer detection and immunotherapy outcomes predictionSemantic proximity Read

Bioinformatics Analysis for Circulating Cell-Free DNA in CancerSemantic proximity Read

5-Hydroxymethylcytosines from Circulating Cell-free DNA as Diagnostic and Prognostic Markers for Hepatocellular CarcinomaSemantic proximity Read

Pilot study demonstrating changes in DNA hydroxymethylation enable detection of multiple cancers in plasma cell-free DNASemantic proximity Read

Towards precision medicine: advances in 5‐hydroxymethylcytosine cancer biomarker discovery in liquid biopsySemantic proximity Read

An integrative analysis of genome-wide 5-hydroxymethylcytosines in circulating cell-free DNA detects noninvasive diagnostic markers for gliomasSemantic proximity Read

Finding new cancer epigenetic and genetic biomarkers from cell-free DNA by combining SALP-seq and machine learningSemantic proximity Read