Article

Causal mediation analysis for time-varying heritable risk factors with Mendelian Randomization

2024-02-12

Abstract excerpt

Understanding the causal mechanisms of diseases is crucial in clinical research. When randomized experiments are unavailable, Mendelian Randomization (MR) leverages genetic mutations to mitigate confounding. However, most MR analyses assume static risk factors, oversimplifying dynamic risk factor effects. The framework of life-course MR addresses this but struggles with limited GWAS cohort sizes and correlations a...

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Literature Corpus work: 70c1904b-b5ba-59e8-9abf-5b16891b0ae2
DOI: 10.1101/2024.02.10.579129

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