Article

E3 ubiquitin ligase Deltex facilitates the expansion of Wingless gradient and antagonizes Wingless signaling through a conserved mechanism of transcriptional effector Armadillo/β-catenin degradation

2023-06-07

Abstract excerpt

<h4>ABSTRACT</h4> The Wnt/Wg pathway controls myriads of biological phenomena throughout the development and adult life of all organisms across the phyla. Thus, an aberrant Wnt signaling is associated with a wide range of pathologies in humans. Tight regulation of Wnt/Wg signaling is required to maintain proper cellular homeostasis. Here we report a novel role of E3 ubiquitin ligase Deltex in Wg signaling regulat...

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Literature Corpus work: 70ab7cd6-1760-5acc-a367-43a4dd9a72f2
DOI: 10.1101/2023.06.06.543920

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