The DTX Protein Family: An Emerging Set of E3 Ubiquitin Ligases in Cancer

Abstract excerpt

Until recently, Deltex (DTX) proteins have been considered putative E3 ligases, based on the presence of an E3 RING domain in their protein coding sequence. The human DTX family includes DTX1, DTX2, DTX3, DTX3L and DTX4. Despite the fact that our knowledge of this class of E3-ubiquitin ligases is still at an early stage, our understanding of their role in oncogenesis is beginning to unfold. In fact, recently...

Topics

Share this publication in a Topic to start or enrich a Post.

• Share to 14-3-3 protein interactions
• Share to Cancer-related Molecular Pathways
• Share to Ubiquitin and proteasome pathways