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Article

The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila.

Molecular genetics and genomics : MGG - 1 Mar 2006

Fuwa Takashi J, Hori Kazuya, Sasamura Takeshi, Higgs Jenny, Baron Martin, Matsuno Kenji

Abstract excerpt

Notch (N) is a single-pass transmembrane receptor. The N signaling pathway is an evolutionarily conserved mechanism that controls various cell-specification processes. Drosophila Deltex (Dx), a RING-domain E3 ubiquitin ligase, binds to the N intracellular domain, promotes N's endocytic trafficking to late endosomes, and was proposed to activate Suppressor of Hairless [Su(H)]-independent N signaling. However, it...

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PMID: 16395579
DOI: 10.1007/s00438-005-0087-3

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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The first deltex null mutant indicates tissue-specific deltex-dependent Notch signaling in Drosophila.PMID 16395579Read ↗

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