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Article

Roles of Drosophila deltex in Notch receptor endocytic trafficking and activation.

Genes to cells : devoted to molecular & cellular mechanisms - 1 Mar 2011

Yamada Kenta, Fuwa Takashi J, Ayukawa Tomonori, Tanaka Tsubasa, Nakamura Akira, Wilkin Marian B, Baron Martin, Matsuno Kenji

Abstract excerpt

Cell signaling mediated by the Notch receptor (N) regulates many cell-fate decisions and is partly controlled by the endocytic trafficking of N. Drosophila deltex (dx) encodes an evolutionarily conserved regulator of N signaling, an E3-ubiquitin ligase, which ubiquitinates N's intracellular domain. Although Dx was shown to function in N endocytosis in studies of dx over-expression, the roles of endogenous Dx have...

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Identifiers

PMID: 21299753
DOI: 10.1111/j.1365-2443.2011.01488.x

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 5 Sept 2026. Manifest publication-graph-cohort-2026-09-05.1.

Source receipt: pubmed, retrieved 5 Sept 2026.

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