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Article

USP9X Deubiquitylates DVL2 to Regulate WNT Pathway Specification

1 Jul 2019

Abstract excerpt

The WNT signaling network is comprised of multiple receptors that relay various input signals via distinct transduction pathways to execute multiple complex and context-specific output processes. Integrity of the WNT signaling network relies on proper specification between canonical and noncanonical pathways, which presents a regulatory challenge given that several signal transducing elements are shared between...

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PMID: 31340145
DOI: 10.1016/j.celrep.2019.06.083

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