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Article

Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc.

Development (Cambridge, England) - 1 Feb 2005

Han Chun, Yan Dong, Belenkaya Tatyana Y, Lin Xinhua

Abstract excerpt

Drosophila Wingless (Wg) is the founding member of the Wnt family of secreted proteins. During the wing development, Wg acts as a morphogen whose concentration gradient provides positional cues for wing patterning. The molecular mechanism(s) of Wg gradient formation is not fully understood. Here, we systematically analyzed the roles of glypicans Dally and Dally-like protein (Dlp), the Wg receptors Frizzled (Fz)...

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Source

Identifiers

PMID: 15647319
DOI: 10.1242/dev.01636

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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Click a neighbor to travelStep 1 · 12 closest

Drosophila glypicans Dally and Dally-like shape the extracellular Wingless morphogen gradient in the wing disc.PMID 15647319Read ↗

Glypicans shunt the Wingless signal between local signalling and further transport.Semantic proximity Read ↗

A regulatory receptor network directs the range and output of the Wingless signal.Semantic proximity Read ↗

The cell-surface proteoglycan Dally regulates Wingless signalling in Drosophila.Semantic proximity Read ↗

Opposing activities of Dally-like glypican at high and low levels of Wingless morphogen activity.Semantic proximity Read ↗

Non-equivalent roles of Drosophila Frizzled and Dfrizzled2 in embryonic wingless signal transduction.Semantic proximity Read ↗

Dally cooperates with Drosophila Frizzled 2 to transduce Wingless signalling.Semantic proximity Read ↗

Wingless/Wnt signaling in Drosophila: the pattern and the pathway.Semantic proximity Read ↗

Wingless transduction by the Frizzled and Frizzled2 proteins of Drosophila.Semantic proximity Read ↗

Interactions between Wingless and DFz2 during Drosophila wing development.Semantic proximity Read ↗

A screen for genes regulating the wingless gradient in Drosophila embryos.Semantic proximity Read ↗

Dispatched mediates Hedgehog basolateral release to form the long-range morphogenetic gradient in the Drosophila wing disk epithelium.Semantic proximity Read ↗

The Wingless morphogen gradient is established by the cooperative action of Frizzled and Heparan Sulfate Proteoglycan receptors.Semantic proximity Read ↗

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