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Mapping of mitogen and metabolic sensitivity in organoids defines requirements for human hepatocyte growth

13 May 2024

Abstract excerpt

Mechanisms underlying human hepatocyte growth in development and regeneration are incompletely understood. In vitro, human fetal hepatocytes (FH) can be robustly grown as organoids, while adult primary human hepatocyte (PHH) organoids remain difficult to expand, suggesting different growth requirements between fetal and adult hepatocytes. Here, we characterize hepatocyte organoid outgrowth using temporal...

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PMID: 38740814
DOI: 10.1038/s41467-024-48550-4

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