Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Topics Community

Article

Characterization of diseased primary human hepatocytes in an all-human cell-based triculture system

21 Mar 2024

Abstract excerpt

Liver diseases, including NAFLD, are a growing worldwide health concern. Currently, there is a lack of suitable in vitro models that sustain basic primary human hepatocyte (PHH) morphology and functionality while supporting presentation of disease-associated phenotypic characteristics such as lipid accumulation and inflammasome activation. In TruVivo, an all-human triculture system (hTCS), basic metabolic...

Topics

Join the communities discussing this publication.

Liver Disease Diagnosis and Treatment
Liver physiology and pathology
Pancreatic function and diabetes

Source

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Identifiers

PMID: 38514705
DOI: 10.1038/s41598-024-57463-7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 31 Aug 2026.

Community interpretation

Discuss the evidence

Ask a question, add context or challenge an interpretation. Community activity is separate from scientific evidence strength.

0

discussions

0

replies

Citations encouraged

Claims remain attributable.

No discussion yet

Be the first to add a careful, cited interpretation.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Characterization of diseased primary human hepatocytes in an all-human cell-based triculture systemPMID 38514705Read ↗

The morphology, functionality, and longevity of a novel all human hepatic cell-based tri-culture systemSemantic proximity Read ↗

Mass Generation and Long-term Expansion of Hepatobiliary Organoids from Adult Primary Human HepatocytesSemantic proximity Read ↗

Physiologically relevant media are associated with overlapping metabolic responses in primary human hepatocytes and Huh7 cellsSemantic proximity Read ↗

Novel hepatocyte-like liver organoids recapitulate crucial mature hepatic functionsSemantic proximity Read ↗

hiPSC-derived hepatocytes closely mimic the lipid profile of primary hepatocytes: A future personalised cell model for studying the lipid metabolism of the liver.Semantic proximity Read ↗

Generation of liver organoids from human induced pluripotent stem cells as liver fibrosis and steatosis modelsSemantic proximity Read ↗

Liver organoids: established tools for disease modeling and drug developmentSemantic proximity Read ↗

A 3D primary human cell-based in vitro model of non-alcoholic steatohepatitis for efficacy testing of clinical drug candidatesSemantic proximity Read ↗

Dedifferentiation of Primary Hepatocytes is Accompanied with Reorganization of Lipid Metabolism Indicated by Altered Molecular Lipid and miRNA ProfilesSemantic proximity Read ↗

Human Three-Dimensional Hepatic Models: Cell Type Variety and Corresponding ApplicationsSemantic proximity Read ↗

Standard Protocols for Characterising Primary and In Vitro‐Generated Human HepatocytesSemantic proximity Read ↗

Characterization Of Human Pluripotent Stem Cell-Derived Hepatocytes With Adult Features And Potential For Modeling Metabolic DiseasesSemantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.