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Article

Pan-cancer proteogenomic interrogation of the Ubiquitin Proteasome System

2026-03-26

Abstract excerpt

<h4>Summary</h4> Somatic mutations rewire the ubiquitin–proteasome system (UPS) to support tumor growth, but the proteome-wide consequences of cancer-driver alterations on UPS composition remain incompletely understood. Using harmonized proteogenomic data from up to 11 CPTAC cohorts, we performed an integrated pan-cancer analysis of UPS protein dysregulation, prognostic associations, and mutation-driven remodelin...

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Identifiers and source

Literature Corpus work
c08d1f6e-ed50-57c5-ba66-1b38525dff2b
DOI
10.64898/2026.03.23.713741
Open publication

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Pan-cancer proteogenomic interrogation of the Ubiquitin Proteasome SystemDOI 10.64898/2026.03.23.713741
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