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Article

Molecular mechanisms of alpha-synuclein neurodegeneration.

Biochimica et biophysica acta - 1 Jul 2009

Waxman Elisa A, Giasson Benoit I

Abstract excerpt

alpha-Synuclein is an abundant highly charged protein that is normally predominantly localized around synaptic vesicles in presynaptic terminals. Although the function of this protein is still ill-defined, genetic studies have demonstrated that point mutations or genetic alteration (duplications or triplications) that increase the number of copies of the alpha-synuclein (SCNA) gene can cause Parkinson's disease...

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Identifiers

PMID: 18955133
DOI: 10.1016/j.bbadis.2008.09.013
PMCID: PMC2756732

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PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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