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Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative disease

23 Jun 2016

Abstract excerpt

Common neurodegenerative proteinopathies, such as Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by the misfolding and aggregation of toxic protein species, including the amyloid beta (Aß) peptide, microtubule-associated protein Tau (Tau), and alpha-synuclein (αSyn) protein. These factors also show toxicity in Drosophila; however, potential limitations of prior studies include poor...

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PMID: 27338814
DOI: 10.1186/s40478-016-0333-4

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