Discover Community Create You

Loading publication...

Noodle always counts identifier-free feature events for service operation. With your permission, Google Analytics can also estimate audience and engagement. Search text, publication identifiers, cookies, IP addresses and browser fingerprints are never included in Noodle's first-party event counters.

Privacy details

Article

Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's disease

14 Jan 2014

Abstract excerpt

Clinical and pathological studies have suggested considerable overlap between tauopathies and synucleinopathies. Several genome-wide association studies have identified alpha-Synuclein (SNCA) and Tau (MAPT) polymorphisms as common risk factors for sporadic Parkinson's disease (PD). However, the mechanisms by which subtle variations in the expression of wild-type SNCA and MAPT influence risk for PD and the...

Read the complete abstract on PubMed

Topics

Share this publication in a Topic to start or enrich a Post.

Share to Alzheimer's disease research and treatments
Share to Cholinesterase and Neurodegenerative Diseases
Share to Parkinson's Disease Mechanisms and Treatments

Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Source

Identifiers

PMID: 24430504
DOI: 10.1093/hmg/ddu011

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 8 Sept 2026.

Related research

Semantic proximity does not establish scientific evidence.

Research trail→

Click a neighbor to travelStep 1 · 12 closest

Interactions between Tau and α-synuclein augment neurotoxicity in a Drosophila model of Parkinson's diseasePMID 24430504Read ↗

Roles of α-Synuclein and Disease-Associated Factors in Drosophila Models of Parkinson's Disease.Semantic proximity Read ↗

Glial α‐synuclein promotes neurodegeneration characterized by a distinct transcriptional program in vivoSemantic proximity Read ↗

-Synuclein modifies mutant huntingtin aggregation and neurotoxicity in DrosophilaSemantic proximity Read ↗

Presynaptic accumulation of α-synuclein causes synaptopathy and progressive neurodegenerationSemantic proximity Read ↗

Uncoupling neuronal death and dysfunction in Drosophila models of neurodegenerative diseaseSemantic proximity Read ↗

Analysis of α-syn and parkin interaction in mediating neuronal death in Drosophila model of Parkinson's diseaseSemantic proximity Read ↗

Cytoskeleton proteins are modulators of mutant tau-induced neurodegeneration in Drosophila.Semantic proximity Read ↗

Drosophila Models of Tauopathies: What Have We Learned?Semantic proximity Read ↗

Parkinson's disease risk genes act in glia to control neuronal α-synuclein toxicity.Semantic proximity Read ↗

Loss of Tau results in defects in photoreceptor development and progressive neuronal degeneration in Drosophila.Semantic proximity Read ↗

Physiology and pathophysiology of alpha-synuclein. Cell culture and transgenic animal models based on a Parkinson's disease-associated protein.Semantic proximity Read ↗

A new Drosophila model to study the interaction between genetic and environmental factors in Parkinson's disease.Semantic proximity Read ↗

⌁Select a neighboring publication to make it the new centre.