Article

Genome-wide co-essentiality analysis in <i>Mycobacterium tuberculosis</i> reveals an itaconate defense enzyme module

2022-09-28

Abstract excerpt

Genome-wide random mutagenesis screens using transposon sequencing (TnSeq) have been a cornerstone of functional genetics in Mycobacterium tuberculosis ( Mtb ), helping to define gene essentiality across a wide range of experimental conditions. Here, we harness a recently compiled TnSeq database to identify pairwise correlations of gene essentiality profiles (i.e. co-essentiality analysis) across the Mtb genome...

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Literature Corpus work: 702e736f-e1b5-519e-beaa-7a501d8d0ec7
DOI: 10.1101/2022.09.27.509804

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