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Peptidoglycan synthesis in <i>Mycobacterium tuberculosis</i> is organized into networks with varying drug susceptibility

5 Oct 2015

Abstract excerpt

Peptidoglycan (PG), a complex polymer composed of saccharide chains cross-linked by short peptides, is a critical component of the bacterial cell wall. PG synthesis has been extensively studied in model organisms but remains poorly understood in mycobacteria, a genus that includes the important human pathogen Mycobacterium tuberculosis (Mtb). The principle PG synthetic enzymes have similar and, at times,...

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PMID: 26438867
DOI: 10.1073/pnas.1514135112

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