Article
Estimating the mutation load in human genomes.
Nature reviews. Genetics - 1 Jun 2015
Henn Brenna M, Botigué Laura R, Bustamante Carlos D, Clark Andrew G, Gravel Simon
Abstract excerpt
Next-generation sequencing technology has facilitated the discovery of millions of genetic variants in human genomes. A sizeable fraction of these variants are predicted to be deleterious. Here, we review the pattern of deleterious alleles as ascertained in genome sequencing data sets and ask whether human populations differ in their predicted burden of deleterious alleles - a phenomenon known as mutation load....
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