Article

Integrating single-cell and bulk transcriptomic perturbation resources reveals complementary therapeutic spaces for drug repurposing

2026-08-31

Abstract excerpt

<title>Abstract</title> <p> Background Transcriptome-based drug repurposing can accelerate therapeutic discovery, but is limited by fragmented resources, inconsistent quality control, and reliance on single perturbation databases. Methods We developed CDRPipe ( <bold>C</bold> omputational <bold>D</bold> rug <bold>R</bold> epurposing <bold>Pipe</bold> line), a unified framework that interrogates disease...

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Literature Corpus work: 70245452-c7df-55c0-9763-cd2c01a20fba
DOI: 10.21203/rs.3.rs-10606217/v1

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