Article

RANKOR: Direct Drug Prioritization from Bulk and Single-Cell Transcriptomic Signatures

2026-05-21

Abstract excerpt

<h4>Background</h4> Prioritizing therapeutics from transcriptomic data remains a key challenge in precision medicine. Signature reversal approaches, most commonly implemented through Gene Set Enrichment Analysis (GSEA), have been widely used to match disease signatures to candidate drugs. However, enrichment-based methods can be sensitive to noise and are restricted to previously profiled compounds <h4>Methods</h...

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Literature Corpus work: 0ca5eb2c-cf50-509c-81d0-95201f2d1480
DOI: 10.64898/2026.05.20.726471

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