Article

scDrugPrio: A framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseases

2023-11-13

Abstract excerpt

<h4>Background</h4> Ineffective drug treatment is a major problem for many patients with immune-mediated inflammatory diseases (IMIDs). Important reasons are the lack of systematic solutions for drug prioritisation and repurposing based on characterisation of the complex and heterogeneous cellular and molecular changes in IMIDs. <h4>Methods</h4> Here, we propose a computational framework, scDrugPrio, which const...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 2d664934-d7b3-5cda-a4cb-c5eaf438a098
DOI: 10.1101/2023.11.08.566249

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

scDrugPrio: A framework for the analysis of single-cell transcriptomics to address multiple problems in precision medicine in immune-mediated inflammatory diseasesDOI 10.1101/2023.11.08.566249Read

A validated single-cell-based strategy to identify diagnostic and therapeutic targets in complex diseasesSemantic proximity Read

Characterizing cellular subpopulations critical to treatment response in autoimmune diseasesSemantic proximity Read

Harnessing gene-gene interactions via an RNA-Sequencing network analysis framework improves precision medicine prediction in rheumatoid arthritisSemantic proximity Read

EVA: a Foundation Model Advancing Translational Drug Development in Immuno-InflammationSemantic proximity Read

Integration of immunome with disease-gene network reveals common cellular mechanisms between IMIDs and drug repurposing strategiesSemantic proximity Read

A network-based model for drug repurposing in Rheumatoid ArthritisSemantic proximity Read

Compendium of Synovial Signatures Identifies Pathologic Characteristics for Predicting Treatment Response in Rheumatoid ArthritisSemantic proximity Read

Single-cell based integrative analysis of transcriptomics and genetics reveals robust associations and complexities for inflammatory diseasesSemantic proximity Read

Integrated multi-omics strategies for identifying novel therapies in psoriasis.Semantic proximity Read

GenesetDiseaseDrugNetwork (GDDN): a web server for disease enrichment and drug prioritizationSemantic proximity Read

A novel translational in-silico indication discovery framework identifies indications and predictive biomarkers for cenerimodSemantic proximity Read

Integrated analysis of single-cell RNA-seq, bulk RNA-seq, Mendelian randomization, and eQTL reveals T cell-related nomogram model and subtype classification in rheumatoid arthritisSemantic proximity Read