Article

Integrating single-cell and bulk transcriptomic perturbation resources reveals complementary therapeutic spaces for drug repurposing

2026-07-22

Abstract excerpt

<h4>ABSTRACT</h4> Transcriptome-based drug repurposing can accelerate therapeutic discovery, but is limited by fragmented resources, inconsistent quality control, and reliance on single perturbation databases. We developed CDRPipe ( C omputational D rug R epurposing Pipe line), a unified framework that interrogates disease signatures against drug perturbation signatures generated by distinct experimental tech...

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Literature Corpus work: f69aade0-1c0d-5fcf-ac5f-10b80eb97106
DOI: 10.64898/2026.07.17.739227

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