Article

STDrug enables spatially informed personalized drug repurposing from spatial transcriptomics

2026-04-07

Abstract excerpt

Drug repurposing offers a scalable route to accelerate therapeutic discovery, yet existing approaches based on single-cell RNA sequencing (scRNA-seq) often overlook spatial tissue context, limiting their ability to capture microenvironment-dependent drug responses. Here we present STDrug , a spatially informed computational framework that integrates spatial transcriptomics, graph-based modeling, and multimodal le...

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Literature Corpus work: 2ed830bb-9e3b-59d4-836e-1e4abaed0cd6
DOI: 10.64898/2026.04.03.715101

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