Article

Immune disease variants modulate gene expression in regulatory CD4+ T cells and inform drug targets

2019-05-31

Abstract excerpt

Identifying cellular functions dysregulated by disease associated variants could implicate novel pathways for drug targeting or modulation in cell therapies. Variants associated with immune diseases point towards the role of CD4+ regulatory T cells (Tregs), cell type critical for immune homeostasis. To translate the effects of immune disease alleles on Treg function we mapped genetic regulation (QTL) of gene expre...

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Literature Corpus work: 701772ae-09e8-509c-b074-82eccf256657
DOI: 10.1101/654632

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