Article

The 3D chromatin landscape of rhabdomyosarcoma

2022-12-05

Abstract excerpt

<h4>ABSTRACT</h4> Rhabdomyosarcoma (RMS) is a pediatric soft tissue cancer with a lack of precision therapy option for patients. We hypothesized that with a general paucity of known mutations in RMS, chromatin structural driving mechanisms are essential for tumor proliferation. Thus, we carried out high-depth in situ Hi-C in representative cell lines and patient-derived xenografts to understand chromatin archite...

Topics

Open a Topic to create a Post that cites this publication.

Identifiers and source

Literature Corpus work: 7000ab75-897d-534f-9a36-4217b7cc82e9
DOI: 10.1101/2022.12.05.519166

Open publication

Related research

Semantic proximity does not establish scientific evidence.

Click a neighbor to travelStep 1 · 12 closest

The 3D chromatin landscape of rhabdomyosarcomaDOI 10.1101/2022.12.05.519166Read

Comparative modes of chromatin engagement by PAX::FOXO1 fusions in rhabdomyosarcomaSemantic proximity Read

Rhabdomyosarcoma: How Advanced Molecular Methods Are Shaping the Diagnostic and Therapeutic Paradigm.Semantic proximity Read

Dependence of PAX3-FOXO1 chromatin occupancy on ETS1 at important disease-promoting genes exposes new targetable vulnerability in Fusion-Positive RhabdomyosarcomaSemantic proximity Read

Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma.Semantic proximity Read

Complex structural variation is prevalent and highly pathogenic in pediatric solid tumorsSemantic proximity Read

Genomic Classification and Clinical Outcome in Rhabdomyosarcoma: A Report From an International Consortium.Semantic proximity Read

KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1-driven and independent disease-promoting gene expression in fusion-positive Rhabdomyosarcoma.Semantic proximity Read

Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivoSemantic proximity Read

Pioneer activity of an oncogenic fusion transcription factor at inaccessible chromatinSemantic proximity Read

Single-cell mapping of tumor heterogeneity in pediatric rhabdomyosarcoma reveals developmental signatures with therapeutic relevanceSemantic proximity Read

Methylation profiling reveals novel molecular classes of rhabdomyosarcoma.Semantic proximity Read

Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors.Semantic proximity Read