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Article

KDM3A/Ets1 epigenetic axis contributes to PAX3/FOXO1-driven and independent disease-promoting gene expression in fusion-positive Rhabdomyosarcoma.

Molecular oncology - 1 Oct 2020

Sobral Lays M, Hicks Hannah M, Parrish Janet K, McCann Tyler S, Hsieh Joseph, Goodspeed Andrew, Costello James C, Black Joshua C, Jedlicka Paul

Abstract excerpt

Rhabdomyosarcoma (RMS) is the most common soft tissue sarcoma in children and young adults. RMS exists as two major disease subtypes, oncofusion-negative RMS (FN-RMS) and oncofusion-positive RMS (FP-RMS). FP-RMS is characterized by recurrent PAX3/7-FOXO1 driver oncofusions and is a biologically and clinically aggressive disease. Recent studies have revealed FP-RMS to have a strong epigenetic basis. Epigenetic...

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Share to Enhancer Elements, Genetic
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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

Share to Forkhead Box Protein O1

Share to Jumonji Domain-Containing Histone Demethylases

Share to Oncogene Proteins, Fusion

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Identifiers

PMID: 32697014
DOI: 10.1002/1878-0261.12769
PMCID: PMC7530783

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