Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors.

doi:10.1158/2159-8290.CD-13-0639

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Article

Comprehensive genomic analysis of rhabdomyosarcoma reveals a landscape of alterations affecting a common genetic axis in fusion-positive and fusion-negative tumors.

Cancer discovery - 1 Feb 2014

Shern Jack F, Chen Li, Chmielecki Juliann, Wei Jun S, Patidar Rajesh, Rosenberg Mara, Ambrogio Lauren, Auclair Daniel, Wang Jianjun, Song Young K, Tolman Catherine, Hurd Laura, Liao Hongling, Zhang Shile, Bogen Dominik, Brohl Andrew S, Sindiri Sivasish, Catchpoole Daniel, Badgett Thomas, Getz Gad, Mora Jaume, Anderson James R, Skapek Stephen X, Barr Frederic G, Meyerson Matthew, Hawkins Douglas S, Khan Javed

Abstract excerpt

UNLABELLED: Despite gains in survival, outcomes for patients with metastatic or recurrent rhabdomyosarcoma remain dismal. In a collaboration between the National Cancer Institute, Children's Oncology Group, and Broad Institute, we performed whole-genome, whole-exome, and transcriptome sequencing to characterize the landscape of somatic alterations in 147 tumor/normal pairs. Two genotypes are evident in...

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Identifiers

PMID: 24436047
DOI: 10.1158/2159-8290.CD-13-0639
PMCID: PMC4462130

Genes

BCOR
CTNNB1
FGFR4
HRAS
KRAS
NRAS
PAX3
PAX7

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-08.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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