Article

Rhabdomyosarcoma fusion oncoprotein initially pioneers a neural signature in vivo

2024-07-16

Abstract excerpt

Fusion-positive rhabdomyosarcoma is an aggressive pediatric cancer molecularly characterized by arrested myogenesis. The defining genetic driver, PAX3::FOXO1, functions as a chimeric gain-of-function transcription factor. An incomplete understanding of PAX3::FOXO1’s in vivo epigenetic mechanisms has hindered therapeutic development. Here, we establish a PAX3::FOXO1 zebrafish injection model and semi-automated ChIP...

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Literature Corpus work: 526f7000-1d45-50ef-aaab-b29f5991417a
DOI: 10.1101/2024.07.12.603270

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