Article
Integrated genetic and epigenetic analysis defines novel molecular subgroups in rhabdomyosarcoma.
Nature communications - 3 Jul 2015
Seki Masafumi, Nishimura Riki, Yoshida Kenichi, Shimamura Teppei, Shiraishi Yuichi, Sato Yusuke, Kato Motohiro, Chiba Kenichi, Tanaka Hiroko, Hoshino Noriko, Nagae Genta, Shiozawa Yusuke, Okuno Yusuke, Hosoi Hajime, Tanaka Yukichi, Okita Hajime, Miyachi Mitsuru, Souzaki Ryota, Taguchi Tomoaki, Koh Katsuyoshi, Hanada Ryoji, Kato Keisuke, Nomura Yuko, Akiyama Masaharu, Oka Akira, Igarashi Takashi, Miyano Satoru, Aburatani Hiroyuki, Hayashi Yasuhide, Ogawa Seishi, Takita Junko
Abstract excerpt
Rhabdomyosarcoma (RMS) is the most common soft-tissue sarcoma in childhood. Here we studied 60 RMSs using whole-exome/-transcriptome sequencing, copy number (CN) and DNA methylome analyses to unravel the genetic/epigenetic basis of RMS. On the basis of methylation patterns, RMS is clustered into four distinct subtypes, which exhibits remarkable correlation with mutation/CN profiles, histological phenotypes and...
Read the complete abstract on PubMedTopics
Share this publication in a Topic to start or enrich a Post.