Article

<i>In vivo</i> functional genomics identifies essentiality of potassium homeostasis in medulloblastoma

2022-07-23

Abstract excerpt

<h4>ABSTRACT</h4> The identification of cancer maintenance genes—driver genes essential to tumor survival—is fundamental for developing effective cancer therapy. Transposon-based insertional mutagenesis screens can identify cancer driver genes broadly but not discriminate maintenance from progression or initiation drivers, which contribute to cancer phenotypes and tumorigenesis, respectively. We engineered a nest...

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Literature Corpus work: 6ffc573b-94b7-5008-a442-09b7341ee4c4
DOI: 10.1101/2022.07.23.501234

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