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Article

Forward genetic screen for malignant peripheral nerve sheath tumor formation identifies new genes and pathways driving tumorigenesis.

Nature genetics - 1 Jul 2013

Rahrmann Eric P, Watson Adrienne L, Keng Vincent W, Choi Kwangmin, Moriarity Branden S, Beckmann Dominic A, Wolf Natalie K, Sarver Aaron, Collins Margaret H, Moertel Christopher L, Wallace Margaret R, Gel Bernat, Serra Eduard, Ratner Nancy, Largaespada David A

Abstract excerpt

Malignant peripheral nerve sheath tumors (MPNSTs) are sarcomas of Schwann cell lineage origin that occur sporadically or in association with the inherited syndrome neurofibromatosis type 1. To identify genetic drivers of MPNST development, we used the Sleeping Beauty (SB) transposon-based somatic mutagenesis system in mice with somatic loss of transformation-related protein p53 (Trp53) function and/or...

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Methodology Data sources Editorial policy Privacy About Contact Helena Bioinformatics

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Source

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Identifiers

PMID: 23685747
DOI: 10.1038/ng.2641
PMCID: PMC3695033

Genes

EGFR

Provenance

PubMed metadata and Literature Corpus relationships. Corpus snapshot updated 7 Sept 2026. Manifest publication-graph-cohort-2026-09-07.1.

Source receipt: pubmed, retrieved 7 Sept 2026.

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